In his early career, Jason Dufner struggled to hold down a place on the PGA Tour. He became a member of the PGA Tour in 2004 and the Nationwide Tour in 2001, 2002, 2003, 2005 and 2006. Dufner won two events during his time on the Nationwide Tour, the BUY.COM Wichita Open in 2001 and the LaSalle Bank Open in 2006.
In 2009, Dufner finished in the top-10 on six occasions, including a third place finish at the RBC Canadian Open, and a runner up place at the Deutsche Bank Championship, part of the FedEx Cup playoffs. As a result Dufner went on to finish the year 11th in the FedEx Cup standings and 33rd on the year’s money list.