In his early career, Jason Dufner struggled to hold down a place on the PGA Tour. He became a member of the PGA Tour in 2004 and the Nationwide Tour in 2001, 2002, 2003, 2005 and 2006. Dufner won two events during his time on the Nationwide Tour, the BUY.COM Wichita Open in 2001 and the LaSalle Bank Open in 2006.
In 2009, Dufner finished in the top-10 on six occasions, including a third place finish at the RBC Canadian Open, and a runner up place at the Deutsche Bank Championship, part of the FedEx Cup playoffs. As a result Dufner went on to finish the year 11th in the FedEx Cup standings and 33rd on the year’s money list.
Jason Dufner had a less successful 2010 season, recording only two top-10 finishes. However, his best finish of the year came in a major championship, at the 2010 PGA Championship at Whistling Straits. In 2011, Dufner had a chance to win his first PGA Tour title at the Waste Management Phoenix Open at TPC Scottsdale when he finished tied for the lead at 18-under-par after 72 holes, before eventually losing in a playoff to Mark Wilson.
At the 2011 PGA Championship in Atlanta, Dufner was in contention to win his first major and maiden PGA Tour title, when he entered the final round in the last group but lost out Keegan Bradley after he made triple bogey.
Dufner continued his good form in 2012 by sharing the 36-hole lead at the Masters, but faded on the weekend to finish T24.Three weeks later at the Zurich Classic of New Orleans, Dufner won for the first time on the PGA Tour in his 164th start when he defeated Ernie Els on the second hole of a sudden death playoff.
Jason Dufner won his maiden major championship at the 2013 PGA Tournament with a two-stroke victory at Oak Hill Country Club in Rochester, New York.